منابع مشابه
Why animal studies are still being used in drug development.
In the European Union, about 3.6 million animals per year (30% of all the animals used) are used for drug development.1 Animal studies are the global standard used to evaluate the safety, efficacy and quality of drugs before these drugs are tested in humans. However, the value of animal studies to predict risks for humans has never been extensively established.2 In fact, many studies indicate t...
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Most previous studies comparing lung isolation methods and devices have been performed by anesthesiologists who had extensive experience in thoracic anesthesia. With the increasing demand for one-lung ventilation, it is also important to define which device can be used most effectively by occasional users. In this issue, Campos et al. report on a study comparing the success rates of three diffe...
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To further explore controversies surrounding parental presence and children’s anxiety during anesthesia induction, Caldwell-Andrews et al. devised and tested a measure to examine parents’ motivation to be present during the induction process: Motivation for Parental Presence during Induction of Anesthesia (MPPIA). The team then used the newly created measure to determine if the level of parent ...
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To address debates over recommended perioperative fluid management, Nisanevich et al. designed a randomized prospective study to compare liberal versus restricted fluid administration during intraabdominal surgery. The team enrolled 152 patients scheduled to undergo intraabdominal surgery, and randomly assigned half of them (n 75) to receive liberal amounts of lactated Ringer’s solution (bolus ...
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While several risk factors have been identified as leading to laryngeal injury during general anesthesia, the quality of endotracheal intubation has not been clearly implicated. Accordingly, Mencke et al. recruited 80 healthy volunteers scheduled to undergo elective ear surgery and randomly assigned them to one of two groups. The first group received 0.5 mg/kg atracurium prior to intubation, wh...
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/31777